• Corpus ID: 58669191

Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway.

  title={Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway.},
  author={Yuening Zhang and Guoxin Li and Chao Ji},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  volume={23 6},
  • Yuening ZhangGuoxin LiC. Ji
  • Published 1 November 2018
  • Biology, Chemistry, Medicine
  • Journal of B.U.ON. : official journal of the Balkan Union of Oncology
PURPOSE Cervical cancer is one of the prevalently diagnosed cancers in women worldwide. In this study the antiproliferative and anticancer effects of Salviolone were evaluated against HeLa cervical cancer cell line along with determining the anticancer mode of action. METHODS MTT assay was employed to examine the proliferation rate of HeLa cells. Transmission electron microscopy (TEM) was used for the detection of the autophagic cell death. The cell invasion and migration were investigated by… 

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