Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin.

@article{Bhatia1999InhibitionOH,
  title={Inhibition of human carcinoma cell growth and DNA synthesis by silibinin, an active constituent of milk thistle: comparison with silymarin.},
  author={Neehar Bhatia and Jie Zhao and Douglas M. Wolf and Rajesh Agarwal},
  journal={Cancer letters},
  year={1999},
  volume={147 1-2},
  pages={77-84}
}
Several studies from our laboratory have shown the cancer chemopreventive and anti-carcinogenic effects of silymarin, a flavonoid antioxidant isolated from milk thistle, in long-term tumorigenesis models and in human prostate, breast and cervical carcinoma cells. Since silymarin is composed mainly of silibinin with small amounts of other stereoisomers of silibinin, in the present communication, studies were performed to assess whether the cancer preventive and anti-carcinogenic effects of… CONTINUE READING

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