Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D3 metabolites.

  title={Inhibition of human cancer cell growth by 1,25-dihydroxyvitamin D3 metabolites.},
  author={R J Frampton and S A Omond and John A. Eisman},
  journal={Cancer research},
  volume={43 9},
Specific high-affinity 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] receptors, which can undergo hormone-dependent activation and nuclear localization, have been demonstrated in a wide variety of established human cancer cell lines and surgically obtained human cancer tissues. 1,25-(OH)2D3 has been reported by some workers to stimulate cancer cell replication at low "physiological" concentrations and by ourselves and others to inhibit at higher concentrations. We report here that 1,25-(OH)2D3 had a… CONTINUE READING


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