Inhibition of human and pig ureter motility in vitro and in vivo by the K(+) channel openers PKF 217-744b and nicorandil.

@article{Weiss2002InhibitionOH,
  title={Inhibition of human and pig ureter motility in vitro and in vivo by the K(+) channel openers PKF 217-744b and nicorandil.},
  author={Ruth Weiss and Meike Mevissen and Daniela S Hauser and G{\"u}nter Scholtysik and Christopher J. Portier and Bernhard Walter and Urs E Studer and Hansjoerg Danuser},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 2},
  pages={651-8}
}
The relaxing property of the K(+) channel opener and nitric oxide donor nicorandil and the new K(+) channel opener PKF 217-744b was investigated on isolated human ureteral tissue in vitro and in intact ureters of anesthetized pigs in vivo. In addition, nicorandil and its antagonists, glibenclamide and methylene blue, were tested on isolated pig ureter tissue in vitro. Nicorandil decreased the frequency of spontaneous contractions in isolated pig ureter rings. This effect was antagonized by… CONTINUE READING
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