Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells.

@article{Bellinghausen2001InhibitionOH,
  title={Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells.},
  author={I Bellinghausen and U Brand and Kerstin Steinbrink and Alexander H Enk and Juergen Knop and Joachim Saloga},
  journal={The Journal of allergy and clinical immunology},
  year={2001},
  volume={108 2},
  pages={
          242-9
        }
}
BACKGROUND Dendritic cells (DCs) are able to induce human allergic T(H)1 responses as well as T(H)2 responses. OBJECTIVE In this study, we examined the effect of antiinflammatory agents such as IL-10 and hydrocortisone (HC) on the accessory function of DCs and the resulting T-cell response, especially that of T(H)2 cells. METHODS Naive and memory CD4(+) T cells from atopic donors were stimulated with autologous allergen-pulsed DCs generated from CD14(+) monocytes by culture with GM-CSF/IL-4… CONTINUE READING
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