Inhibition of human alkaline phosphatases by vanadate.

  title={Inhibition of human alkaline phosphatases by vanadate.},
  author={Lorne E. Seargeant and Robert A. Stinson},
  journal={The Biochemical journal},
  volume={181 1},
Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme. 


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