Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement.

@article{Kassel2008InhibitionOH,
  title={Inhibition of human airway smooth muscle cell proliferation by beta 2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement.},
  author={Karen M. Kassel and Todd A Wyatt and Reynold A Panettieri and Myron L. Toews},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={294 1},
  pages={L131-8}
}
Mechanisms by which beta-adrenergic receptor (beta AR) agonists inhibit proliferation of human airway smooth muscle (HASM) cells were investigated because of their potential relevance to smooth muscle hyperplasia in asthma. We hypothesized that beta AR agonists would inhibit mitogenesis in HASM cells via the beta 2AR, an increase in cAMP, and PKA activation. HASM cells were treated for 24 h with various agents and then analyzed for [3H]thymidine incorporation as a measure of cell proliferation… CONTINUE READING

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