Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract.

@article{Gaudineau2004InhibitionOH,
  title={Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract.},
  author={C{\'e}dric Gaudineau and Rachel Beckerman and Sarah Welbourn and Karine Auclair},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={318 4},
  pages={1072-8}
}
The Ginkgo biloba extract EGb761 was tested for its ability to inhibit the major human cytochrome P450 enzymes (CYPs). The full extract was found to strongly inhibit CYP2C9 (Ki = 14+/- 4 microg/mL), and to a lesser extent, CYP1A2 (Ki = 106 +/- 24 microg/mL), CYP2E1 (Ki = 127 +/- 42 microg/mL), and CYP3A4 (Ki = 155 +/- 43 microg/mL). The terpenoidic and flavonoidic fractions of the extract were tested separately against the same P450s to identify the source of inhibition by EGb761. The… CONTINUE READING

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