Inhibition of human NK cell function by valinomycin, a toxin from Streptomyces griseus in indoor air.

@article{Paananen2000InhibitionOH,
  title={Inhibition of human NK cell function by valinomycin, a toxin from Streptomyces griseus in indoor air.},
  author={Auli Paananen and Raimo Mikkola and Timo Sareneva and Sampsa Matikainen and Maria Andersson and Ikka Julkunen and Mirja S. Salkinoja-Salonen and Tuomo Timonen},
  journal={Infection and immunity},
  year={2000},
  volume={68 1},
  pages={165-9}
}
Streptomyces griseus strains isolated from indoor dust have been shown to synthesize valinomycin. In this report, we show that human peripheral blood lymphocytes treated with small doses (30 ng ml(-1)) of pure valinomycin or high-pressure liquid chromatography-pure valinomycin from S. griseus quickly show mitochondrial swelling and reduced NK cell activity… CONTINUE READING