Inhibition of human NK cell cytotoxicity by induction of cyclic AMP depends on impaired target cell recognition.

@article{Ullberg1983InhibitionOH,
  title={Inhibition of human NK cell cytotoxicity by induction of cyclic AMP depends on impaired target cell recognition.},
  author={M{\aa}ns Ullberg and Mikael Jondal and F Lanefelt and Bertil B. Fredholm},
  journal={Scandinavian journal of immunology},
  year={1983},
  volume={17 4},
  pages={365-73}
}
Induction of cyclic AMP (cAMP) depresses natural killer (NK) cell activity. The present results demonstrate that this is dependent on a decreased capacity of the effector cells to conjugate to target cells. This was found either if dibutyryl-cAMP was used or if cAMP was induced by adenylate cyclase stimulation with prostaglandin E1 (PGE1) or by inhibition of phosphodiesterase activity with the inhibitor ZK 62711. The sites of action for cAMP-induced NK suppression and interferon (IFN)-induced… CONTINUE READING

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