Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives.

Abstract

Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an antineoplastic agent that intercalates into DNA and alters topoisomerase II activity. Unfortunately, this compound displays a number of adverse properties. Therefore, to investigate new ellipticine-based compounds for their potential as topoisomerase II-targeted drugs, we synthesized two novel… (More)
DOI: 10.1016/j.bmcl.2016.02.034

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