Inhibition of hormonal activation of hepatic phosphorylase by chlorpropamide: evidence for an intracellular site of drug action.

@article{Blumenthal1985InhibitionOH,
  title={Inhibition of hormonal activation of hepatic phosphorylase by chlorpropamide: evidence for an intracellular site of drug action.},
  author={Stanley A. Blumenthal and Arnold M. Moses},
  journal={Endocrinology},
  year={1985},
  volume={116 2},
  pages={
          660-4
        }
}
  • Stanley A. Blumenthal, Arnold M. Moses
  • Published 1985
  • Biology, Medicine
  • Endocrinology
  • Phosphorylase a activity was measured in hepatocytes from fed rats, some of which received ip chlorpropamide injections for 5 days preceding death (20 mg/100 g BW X day for 5 days). Chlorpropamide treatment significantly depressed basal phosphorylase a activity and lessened the increments in the activity of this enzyme induced by 10(-10) -10(-8) M glucagon and arginine vasopressin. The reductions in phosphorylase a activity after treatment with chlorpropamide were more than sufficient to… CONTINUE READING