Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.

@article{Neal2011InhibitionOH,
  title={Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation.},
  author={Jessica A. Neal and Van U. Dang and Pauline Douglas and Marc S. Wold and Susan P Lees-Miller and Katheryn Meek},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 8},
  pages={1719-33}
}
How a cell chooses between nonhomologous end joining (NHEJ) and homologous recombination (HR) to repair a double-strand break (DSB) is a central and largely unanswered question. Although there is evidence of competition between HR and NHEJ, because of the DNA-dependent protein kinase (DNA-PK)'s cellular abundance, it seems that there must be more to the repair pathway choice than direct competition. Both a mutational approach and chemical inhibition were utilized to address how DNA-PK affects… CONTINUE READING

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