Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin.

@article{Markova2007InhibitionOH,
  title={Inhibition of histone deacetylation promotes abnormal epidermal differentiation and specifically suppresses the expression of the late differentiation marker profilaggrin.},
  author={Nedialka G Markova and Nevena Karaman-Jurukovska and Adriana Pinkas-Sarafova and Liuben N Marekov and Marcia Simon},
  journal={The Journal of investigative dermatology},
  year={2007},
  volume={127 5},
  pages={1126-39}
}
Reversible protein acetylation modulates higher-order chromatin structure and transcription activity of the genome. The reversible acetylation is executed by the intrinsic acetylase and deacetylase activities of co-regulators associated with the regulatory regions. Compounds capable of inhibiting deacetylase activity are a powerful tool for dissecting the role of protein acetylation in gene function. The ability of the deacetylase inhibitors to preferentially affect the homeostasis of… CONTINUE READING