Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding.

@article{Kee2006InhibitionOH,
  title={Inhibition of histone deacetylation blocks cardiac hypertrophy induced by angiotensin II infusion and aortic banding.},
  author={Hae Jin Kee and Il Suk Sohn and Kwang-Il Nam and Jong Eun Park and Yong Ri Qian and Zhan Yin and Youngkeun Ahn and Myung Ho Jeong and Yung-jue Bang and Nacksung Kim and J Kim and Kyung Keun Kim and Jonathan A. Epstein and Hyun Kook},
  journal={Circulation},
  year={2006},
  volume={113 1},
  pages={51-9}
}
BACKGROUND A number of distinct stress signaling pathways in myocardium cause cardiac hypertrophy and heart failure. Class II histone deacetylases (HDACs) antagonize several stress-induced pathways and hypertrophy. However, cardiac hypertrophy induced by transgenic overexpression of the homeodomain only protein, HOP, can be prevented by the nonspecific HDAC inhibitors trichostatin A and valproic acid, suggesting that alternate targets that oppose class II HDAC function might exist in myocardium… CONTINUE READING