Inhibition of histone deacetylase1 induces autophagy.

  title={Inhibition of histone deacetylase1 induces autophagy.},
  author={Meeyeon Oh and In-Kwon Choi and Ho Jeong Kwon},
  journal={Biochemical and biophysical research communications},
  volume={369 4},
Autophagy is a process where cytoplasmic materials are degraded by lysosomal machinery. Histone deacetylase (HDAC) inhibitors induce autophagy, and HDAC6, one of class II HDAC isotypes, is directly involved in autophagic degradation in the cell. However, it is unclear if class I HDAC isotype such as HDCA1 is involved in this process. To investigate if class I HDAC isotype is involved in autophagy, a specific class I HDAC inhibitor and an siRNA of HDAC1 were used to treat HeLa cells. Autophagic… CONTINUE READING