Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells.

@article{Xu2009InhibitionOH,
  title={Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells.},
  author={Yue Xu and Kyle E Hammerick and Aaron W. James and Antoine Lyonel Carre and Philipp Leucht and Amato J. Giaccia and Michael Thornton Longaker},
  journal={Tissue engineering. Part A},
  year={2009},
  volume={15 12},
  pages={3697-707}
}
Recent studies suggest that oxygen tension has a great impact on the osteogenic differentiation capacity of mesenchymal cells derived from adipose tissue: reduced oxygen impedes osteogenesis. We have found that expansion of mouse adipose-derived stromal cells (mASCs) in reduced oxygen tension (10%) results in increased cell proliferation along with induction of histone deacetylase (HDAC) activity. In this study, we utilized two HDAC inhibitors (HDACi), sodium butyrate (NaB) and valproic acid… CONTINUE READING
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