• Corpus ID: 38217300

Inhibition of histidine, decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine, a new, potent inhibitor of histidine decarboxylase.

@article{Huszti1975InhibitionOH,
  title={Inhibition of histidine, decarboxylation in vivo by 2-hydroxy-5-carbomethoxybenzyloxyamine, a new, potent inhibitor of histidine decarboxylase.},
  author={Zsuzsanna Huszti and Theodore L. Sourkes},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1975},
  volume={192 2},
  pages={
          432-40
        }
}
  • Z. Huszti, T. Sourkes
  • Published 1 February 1975
  • Biology, Chemistry
  • The Journal of pharmacology and experimental therapeutics
Measurements of the rate of expiration of 14CO2 were carried out after the injection into rats of 14C-histidine labeled in the carboxyl group (C-His) or in the imidazole ring (R-His). Intraperitoneal administration of 2-hydroxy-5-carbomethoxybenzyloxyamine, a new potent inhibitor of histidine decarboxylase, reduced the rate of 14CO2 production from C-His and R-His in a dose-dependent manner. The metabolism of C-His was more affected than that of R-His. The inhibitor had no effect on the… 
Induction of gastric histamine synthesis by H2-receptor antagonists: Potentiation of their antisecretory activity by histidine decarboxylase inhibitors
TLDR
Findings provided evidence for the feedback stimulation of gastric HA synthesis by H2-receptor blockers and confirmed the role of HA in the gastric acid secretion.
Metabolism and Excretion of Histamine
TLDR
From the distribution and inducible characteristics of histidine decarboxylase, physiologic roles for histamine have been proposed in microcirculatory control, some cases of rapid growth, and as a neurotransmitter in brain.