Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease

@article{Beghdadi2008InhibitionOH,
  title={Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease},
  author={Walid Beghdadi and Adeline Porcherie and Bradley S Schneider and David Dubayle and Roger P{\'e}ronet and Michel Ren{\'e} Huerre and Takeshi Watanabe and Hiroshi Ohtsu and Jacques A. Louis and Salaheddine M{\'e}cheri},
  journal={The Journal of Experimental Medicine},
  year={2008},
  volume={205},
  pages={395 - 408}
}
From the inoculation of Plasmodium sporozoites via Anopheles mosquito bites to the development of blood-stage parasites, a hallmark of the host response is an inflammatory reaction characterized by elevated histamine levels in the serum and tissues. Given the proinflammatory and immunosuppressive activities associated with histamine, we postulated that this vasoactive amine participates in malaria pathogenesis. Combined genetic and pharmacologic approaches demonstrated that histamine binding to… CONTINUE READING