Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons.

@article{PrangeKiel2006InhibitionOH,
  title={Inhibition of hippocampal estrogen synthesis causes region-specific downregulation of synaptic protein expression in hippocampal neurons.},
  author={Janine Prange-Kiel and Lars Fester and Lepu Zhou and Heidrun Lauke and Jos{\'e} A Carretero and Gabriele M Rune},
  journal={Hippocampus},
  year={2006},
  volume={16 5},
  pages={464-71}
}
Previous studies have shown that synapses and expression of synaptic proteins in hippocampal neurons are regulated by hippocampus-derived estradiol. Here, we compared the effects of this paracrine regulation in different hippocampal regions. In tissue sections, immunohistochemistry followed by semiquantitative image analysis revealed a three-fold higher expression of steroidogenic acute regulatory protein (StAR) and aromatase in neurons of the CA3 than that of the CA1 region and in granule… CONTINUE READING

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