Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task.

@article{Bevilaqua2003InhibitionOH,
  title={Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task.},
  author={L{\'i}a R. M. Bevilaqua and Daniel S. Kerr and Jorge Horacio Medina and Ivan A. Izquierdo and Mart{\'i}n Cammarota},
  journal={The European journal of neuroscience},
  year={2003},
  volume={17 4},
  pages={897-902}
}
Learning initiates a series of plastic events the occurrence of which are required for the storage of information related to the training experience. Several lines of evidence indicate that, in the rat hippocampus, different members of the family of mitogen-activated protein kinases (MAPK) play a key role in the onset of such plastic events. Using SP600125, the newly developed inhibitor of the MAPK c-Jun amino-terminal kinase (JNK), we show a direct involvement of this protein kinase in… CONTINUE READING