Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats.

@article{Pan2012InhibitionOH,
  title={Inhibition of high glucose-induced inflammatory response and macrophage infiltration by a novel curcumin derivative prevents renal injury in diabetic rats.},
  author={Yong Pan and Yi Wang and Lu Cai and Yuepiao Cai and Jie Hu and Congcong Yu and Jianling Li and Zhiguo Feng and Shulin Yang and Xiaokun Li and Guang Liang},
  journal={British journal of pharmacology},
  year={2012},
  volume={166 3},
  pages={1169-82}
}
BACKGROUND AND PURPOSE Inflammation is involved in the development and/or progression of many diseases including diabetic complications. Investigations on novel anti-inflammatory agents may offer new approaches for the prevention of diabetic nephropathy. Our previous bioscreening of synthetic analogues of curcumin revealed C66 as a novel anti-inflammatory compound against LPS challenge in macrophages. In this study, we hypothesized that C66 affects high glucose (HG)-induced inflammation… CONTINUE READING

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