Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

  title={Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.},
  author={Mark N Prichard and Debra C. Quenelle and Caroll B. Hartline and Emma A Harden and Geraldine M. Jefferson and Samuel L Frederick and Shannon L Daily and Richard J. Whitley and Kamal Tiwari and Joseph A. Maddry and John A. Secrist and Earl R. Kern},
  journal={Antimicrobial agents and chemotherapy},
  volume={53 12},
A series of 4'-thionucleosides were synthesized and evaluated for activities against orthopoxviruses and herpesviruses. We reported previously that one analog, 5-iodo-4'-thio-2'-deoxyuridine (4'-thioIDU), exhibits good activity both in vitro and in vivo against two orthopoxviruses. This compound also has good activity in cell culture against many of the herpesviruses. It inhibited the replication of herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus with 50% effective… CONTINUE READING
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