Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.

@article{Furman1979InhibitionOH,
  title={Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate.},
  author={Phillip A. Furman and Marty H St Clair and Janet A. M. Fyfe and Janet L. Rideout and Paul M. Keller and Gertrude Bell Elion},
  journal={Journal of virology},
  year={1979},
  volume={32 1},
  pages={72-7}
}
The effect of the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine) on herpes simplex virus type 1 DNA synthesis was examined. Acycloguanosine inhibited herpesvirus DNA synthesis in virus-infected cells. The synthesis of host cell DNA was only partially inhibited in actively growing cells at acycloguanosine concentrations several hundred… CONTINUE READING