Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates.

@article{Frank1986InhibitionOH,
  title={Inhibition of herpes simplex virus DNA polymerase by purine ribonucleoside monophosphates.},
  author={Karl Frank and Yu Chin Cheng},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 4},
  pages={
          1510-3
        }
}
Purine ribonucleoside monophosphates were found to inhibit chain elongation catalyzed by herpes simplex virus (HSV) DNA polymerase when DNA template-primer concentrations were rate-limiting. Inhibition was fully competitive with DNA template-primer during chain elongation; however, DNA polymerase-associated exonuclease activity was inhibited noncompetitively with respect to DNA. Combinations of 5'-GMP and phosphonoformate were kinetically mutually exclusive in dual inhibitor studies. Pyrimidine… CONTINUE READING