Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol

  title={Inhibition of herpes simplex-1 virus replication by 25-hydroxycholesterol and 27-hydroxycholesterol},
  author={Valeria Cagno and Andrea Civra and Daniela Rossin and Simone Calfapietra and Claudio Caccia and Valerio Leoni and Nicholas Dorma and Fiorella Biasi and Giuseppe Poli and David Lembo},
  booktitle={Redox biology},
Oxysterols are known pleiotropic molecules whose antiviral action has been recently discovered. Here reported is the activity of a panel of oxysterols against HSV-1 with the identification of a new mechanism of action. A marked antiviral activity not only of 25HC but also of 27HC against HSV-1 was observed either if the oxysterols were added before or after infection, suggesting an activity unrelated to the viral entry inhibition as proposed by previous literature. Therefore, the relation… CONTINUE READING


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