Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor

  title={Inhibition of hepatocarcinoma by systemic delivery of Apoptin gene via the hepatic asialoglycoprotein receptor},
  author={D-J Peng and J. Sun and Y-Z Wang and J. Tian and Y-H Zhang and M. Noteborn and S. Qu},
  journal={Cancer Gene Therapy},
  • D-J Peng, J. Sun, +4 authors S. Qu
  • Published 2007
  • Biology, Medicine
  • Cancer Gene Therapy
  • Specificity is a prerequisite for systemic gene therapy of hepatocarcinoma. In vitro, the tumor-specific viral death effector Apoptin selectively induces apoptosis in malignant hepatic cells. Intratumoral treatment of xenografted subcutaneous hepatomas with Apoptin results in tumor regression. Here, we report a systemic delivery vehicle containing the Apoptin gene linked to asialoglycoprotein (Asor), which targets asialoglycoprotein receptor (ASGPR) present only on the surface of hepatocytes… CONTINUE READING
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