Inhibition of hepatitis B virus replication in vivo by nucleoside analogues and siRNA.


BACKGROUND & AIMS Hepatitis B virus (HBV) causes acute and chronic infections that may result in severe liver diseases. Animal models to study new treatment options in vivo have several drawbacks. Therefore, we were interested to establish a new small animal model in which HBV replication and especially new treatment options can be studied easily. METHODS… (More)


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