Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein.

@article{Gordien2001InhibitionOH,
  title={Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein.},
  author={Emmanuel Gordien and Olivier Rosmorduc and C{\'e}cile Peltekian and Florianne Garreau and Christian Br{\'e}chot and Dina Kremsdorf},
  journal={Journal of virology},
  year={2001},
  volume={75 6},
  pages={2684-91}
}
Human MxA is an alpha/beta interferon-inducible intracytoplasmic protein that mediates antiviral activity against several RNA viruses. We had previously shown that overexpression of the hepatitis B virus (HBV) capsid led to selective downregulation of MxA gene expression, suggesting a mechanism by which the virus escapes from the host defense system (O. Rosmorduc, H. Sirma, P. Soussan, E. Gordien, P. Lebon, M. Horisberger, C. Brechot and D. Kremsdorf, J. Gen. Virol. 80:1253-1262, 1999). In the… CONTINUE READING
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