Inhibition of hepatitis B virus X gene expression by 10-23 DNAzymes.

  title={Inhibition of hepatitis B virus X gene expression by 10-23 DNAzymes.},
  author={Wei Hou and Qin Ni and Jianer Wo and Minwei Li and Kezhou Liu and Liwei Chen and Zhongrong Hu and Ronghua Liu and Minjun Hu},
  journal={Antiviral research},
  volume={72 3},
The X protein (HBx) of human hepatitis B virus (HBV) is a transcriptional activator protein. The HBx protein plays an important role in viral replication in HBV infected cells and the liver diseases including hepatitis, cirrhosis and hepatocellular carcinoma (HCC). Therefore, the repression of HBx gene expression by 10-23 DNAzymes might be a good way to inhibit HBV replication and counteract HBV-related liver diseases. We designed three 10-23 DNAzymes with different substrate-recognition… CONTINUE READING


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