Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.

@article{Mabuchi1988InhibitionOH,
  title={Inhibition of hepatic glutathione S-transferases by a major endogenous ligand substance present in uremic serum.},
  author={Hiroshi Mabuchi and Hisashi Nakahashi},
  journal={Nephron},
  year={1988},
  volume={49 4},
  pages={281-3}
}
A major endogenous ligand substance present in uremic serum, 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid, inhibited the in vitro activity of bovine and rat liver glutathione S-transferases. Our results suggested that endogenous ligand substances retained in uremic serum have some toxic activities other than the inhibition of drug binding to serum protein observed in uremia. 

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