Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.

@article{Taniguchi2005InhibitionOH,
  title={Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins.},
  author={Sayuri Taniguchi and Nobuyuki Suzuki and Masami Masuda and Shin-ichi Hisanaga and Takeshi Iwatsubo and Michel Goedert and Masato Hasegawa},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 9},
  pages={7614-23}
}
Tau protein is the major component of the intraneuronal filamentous inclusions that constitute defining neuropathological characteristics of Alzheimer's disease and other tauopathies. The discovery of tau gene mutations in familial forms of frontotemporal dementia has established that dysfunction of the tau protein is sufficient to cause neurodegeneration and dementia. Here we have tested 42 compounds belonging to nine different chemical classes for their ability to inhibit heparin-induced… CONTINUE READING
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