Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver

@article{Robaczewska2001InhibitionOH,
  title={Inhibition of hepadnaviral replication by polyethylenimine-based intravenous delivery of antisense phosphodiester oligodeoxynucleotides to the liver},
  author={Magdalena Robaczewska and Sylviane Guerret and J F R{\'e}my and Isabelle Chemin and W-B Offensperger and Michelle Chevallier and J-P Behr and Anna Jadwiga Podhajska and H. E. Blum and Christian Tr{\'e}po and Lucyna Cova},
  journal={Gene Therapy},
  year={2001},
  volume={8},
  pages={874-881}
}
Antisense oligodeoxynucleotides (ODNs) appear as attractive anti-hepatitis B virus (HBV) agents. We investigated in vivo, in the duck HBV (DHBV) infection model, whether linear polyethylenimine (lPEI)-based intravenous delivery of the natural antisense phosphodiester ODNs (O-ODNs) can prevent their degradation and allow viral replication inhibition in the liver. DHBV-infected Pekin ducklings were injected with antisense O-ODNs covering the initiation codon of the DHBV large envelope protein… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 38 references

Characterization of the antiviral effect of 29,39-dideoxy-29, 39-didehydro-beta-L-5-fluorocytidine in the duck hepatitis B virus infection model

F Le Guerhier
Antimicrob Agents Chemother • 2000

Fomivirsen

G Goodarzi, SC Gross, A Tewari, K Watabe
Drugs • 1999

Protective and therapeutic effect of DNA-based immunization against hepadnavirus large envelope protein

C Rollier
Gastroenterology • 1999

Similar Papers

Loading similar papers…