Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.

@article{Sass2008InhibitionOH,
  title={Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.},
  author={Gabriele Sass and Petra Leukel and Volker Schmitz and Esther Raskopf and Matthias Ocker and Daniel Neureiter and Matthias Meissnitzer and Elena Tasika and Andrea Tannapfel and Gisa Tiegs},
  journal={International journal of cancer},
  year={2008},
  volume={123 6},
  pages={1269-77}
}
Endogenous overexpression of the antiapoptotic protein heme oxygenase 1 (HO-1) has been shown to occur in various cancer diseases and might contribute to cancer progression. We compared the expression levels of HO-1 in human liver to expression levels in hepatocellular carcinoma (HCC), as well as the effect of HO-1 inhibition by small interfering RNA (siRNA) on cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6 and on orthotopic tumor growth in immune-competent… CONTINUE READING

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