Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges.

@article{Wright2001InhibitionOH,
  title={Inhibition of heme detoxification processes underlies the antimalarial activity of terpene isonitrile compounds from marine sponges.},
  author={A. Wright and H. Wang and M. Gurrath and G. K{\"o}nig and G. Kocak and G. Neumann and P. Loria and M. Foley and L. Tilley},
  journal={Journal of medicinal chemistry},
  year={2001},
  volume={44 6},
  pages={
          873-85
        }
}
A series of terpene isonitriles, isolated from marine sponges, have previously been shown to exhibit antimalarial activities. Molecular modeling studies employing 3D-QSAR with receptor modeling methodologies performed with these isonitriles showed that the modeled molecules could be used to generate a pharmacophore hypothesis consistent with the experimentally derived biological activities. It was also shown that one of the modeled compounds, diisocyanoadociane (4), as well as axisonitrile-3 (2… Expand
Antimalarial Peptide and Polyketide Natural Products from the Fijian Marine Cyanobacterium Moorea producens
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