Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

@article{Voso1994InhibitionOH,
  title={Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.},
  author={Maria Teresa Voso and Timothy C. Burn and Gerburg M Wulf and Bing Lim and Gustavo Leone and Daniel G Tenen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 17},
  pages={7932-6}
}
Transcription factors have been shown to play a role as "master switch" factors in the programming of hematopoietic cell commitment and differentiation. PU.1 is a hematopoietic-specific member of the Ets family of transcription factors. In human bone marrow CD34-enriched progenitor cells, PU.1 expression was upregulated during the early phases of… CONTINUE READING