Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.

Abstract

UNLABELLED Endotoxin-mediated proinflammatory cytokines play a significant role in the pathogenesis of acute and chronic liver diseases. Heat shock protein 90 (molecular weight, 90 kDa) (hsp90) functions as an important chaperone of lipopolysaccharide (LPS) signaling and is required for the production of proinflammatory cytokines. We hypothesized that… (More)
DOI: 10.1002/hep.24802

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@article{Ambade2012InhibitionOH, title={Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.}, author={Aditya V Ambade and Donna Catalano and A. L. Lim and Pranoti Mandrekar}, journal={Hepatology}, year={2012}, volume={55 5}, pages={1585-95} }