Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.

@article{Tanaka2005InhibitionOH,
  title={Inhibition of heart transplant injury and graft coronary artery disease after prolonged organ ischemia by selective protein kinase C regulators.},
  author={M. Tanaka and F. Gunawan and Raya D. Terry and K. Inagaki and A. Caffarelli and G. Hoyt and P. Tsao and D. Mochly-Rosen and R. Robbins},
  journal={The Journal of thoracic and cardiovascular surgery},
  year={2005},
  volume={129 5},
  pages={
          1160-7
        }
}
  • M. Tanaka, F. Gunawan, +6 authors R. Robbins
  • Published 2005
  • Medicine
  • The Journal of thoracic and cardiovascular surgery
  • OBJECTIVE Transplanted hearts subjected to prolonged ischemia develop ischemia-reperfusion injury and graft coronary artery disease. To determine the effect of delta-protein kinase C and -protein kinase C on ischemia-reperfusion injury and the resulting graft coronary artery disease induced by prolonged ischemia, we used a delta-protein kinase C-selective inhibitor peptide and an -protein kinase C-selective activator peptide after 30 or 120 minutes of ischemia. METHODS Hearts of piebald viral… CONTINUE READING
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