Inhibition of growth of Leishmania donovani promastigotes by newly synthesized 1,3,4-thiadiazole analogs.

@article{AlQahtani2009InhibitionOG,
  title={Inhibition of growth of Leishmania donovani promastigotes by newly synthesized 1,3,4-thiadiazole analogs.},
  author={Ahmed A Al-Qahtani and Yunus M. Siddiqui and Adnan A Bekhit and Ola A. El-Sayed and Hassan Y Aboul-Enein and Mohammed Noreen Al-Ahdal},
  journal={Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society},
  year={2009},
  volume={17 3},
  pages={227-32}
}
Leishmania donovani, the causative agent of visceral leishmaniasis, is transmitted by sand flies and replicates intracellularly in their mammalian host cells. The emergence of drug-resistant strains has hampered efforts to control the spread of the disease worldwide. Forty-four 1,3,4-thiadiazole derivatives and related compounds were tested in vitro for possible anti-leishmanial activity against the promastigotes of L. donovani. Micromolar concentrations of these agents were used to study the… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS