Inhibition of growth of Chlamydia trachomatis by tumor necrosis factor is accompanied by increased prostaglandin synthesis.

@article{Holtmann1990InhibitionOG,
  title={Inhibition of growth of Chlamydia trachomatis by tumor necrosis factor is accompanied by increased prostaglandin synthesis.},
  author={Helmut Holtmann and Yonat Shemer-Avni and Klaus Wessel and Israel Sarov and David Wallach},
  journal={Infection and immunity},
  year={1990},
  volume={58 10},
  pages={3168-72}
}
Development of Chlamydia trachomatis (L2/434/Bu) in HEp-2 cells was inhibited by treatment of the cells with recombinant human alpha tumor necrosis factor (TNF). In the infected cultures that were treated with TNF, high concentrations of prostaglandin E2(PGE2) were detected, exceeding by far the concentrations found in TNF-treated but uninfected cells or in infected cells that were not treated with TNF. PGE2 levels increased gradually for 2 days after infection. Raising the tryptophan… CONTINUE READING