Inhibition of granulosa cell differentiation by dioctanoylglycerol--a novel activator of protein kinase C.

Abstract

The actions of dioctanoylglycerol, a novel and specific activator of protein kinase C, on granulosa cell steroidogenesis and LH/hCG receptor induction were examined in vitro. Granulosa cells were cultured for 2 days in media containing 100 nM androstenedione. FSH treatment stimulated progesterone, 20 alpha-hydroxy-pregn-4-en-3-one (20 alpha-OH-P) and… (More)

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