Inhibition of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana by mannosamine.

  title={Inhibition of glycosylphosphatidylinositol biosynthesis in Leishmania mexicana by mannosamine.},
  author={Mark C. Field and Enrique Medina-Acosta and George A. M. Cross},
  journal={The Journal of biological chemistry},
  volume={268 13},
In several Leishmania species, glycosylated inositol phospholipids exist as free lipids, as membrane protein anchors, and as the membrane-binding moieties of the lipophosphoglycans. Both the glycolipid-anchored cell surface metalloproteinase, gp63, and the lipophosphoglycans have been proposed to be involved in cell invasion. Moreover, the lipophosphoglycans have been implicated in the survival of Leishmania in the parasitophorous vacuole of the host macrophage. In this report we show that… CONTINUE READING


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