Inhibition of glycosylphosphatidylinositol anchor formation by mannosamine.

@article{Pan1992InhibitionOG,
  title={Inhibition of glycosylphosphatidylinositol anchor formation by mannosamine.},
  author={Y. T. Pan and Tetsu Kamitani and Chidambaram Bhuvaneswaran and Youssef Hallaq and Christopher D. Warren and Edward T H Yeh and Alan David Elbein},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 29},
  pages={
          21250-5
        }
}
Many eucaryotic cell surface proteins are anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI), of which the core region is highly conserved from protozoa to mammalian cells. Previous studies (Lisanti, M. P., Field, M. C., Caras, I. W., Menon, A. K., and Rodiguez-Boulan, E. (1991) EMBO J. 10, 1969-1977) showed that mannosamine blocked the expression of a recombinant GPI-anchored protein in Madin-Darby canine kidney cells and converted this protein to an unpolarized secretory… Expand
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