Inhibition of glycosylation processes: the reaction between pyridoxamine and glucose.

@article{Adrover2005InhibitionOG,
  title={Inhibition of glycosylation processes: the reaction between pyridoxamine and glucose.},
  author={Miquel Adrover and Bartolom{\'e} Vilanova and Francisco Mu{\~n}oz and Josefa Donoso},
  journal={Chemistry & biodiversity},
  year={2005},
  volume={2 7},
  pages={964-75}
}
Glycosylation of proteins by glucose produces toxic and immunogenic compounds called 'advanced glycosylation end products' (AGEs), which are the origin of pathological symptoms in various chronic diseases. In this work, a kinetic study of the reaction between glucose (2) and pyridoxamine (1)--a potent inhibitor of AGEs formation both in vivo and in vitro--was conducted. The NH2 group of pyridoxamine was found to react with the C=O group of glucose to form the Schiff base 9 (Scheme 2… CONTINUE READING

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