• Corpus ID: 9554712

Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.

@article{Cuzzocrea2006InhibitionOG,
  title={Inhibition of glycogen synthase kinase-3beta attenuates the development of carrageenan-induced lung injury in mice.},
  author={Salvatore Cuzzocrea and Concetta Crisafulli and Emanuela Mazzon and Emanuela Esposito and Carmelo Muià and Maha Abdelrahman and Rosanna Di Paola and Christoph Thiemermann},
  journal={British journal of pharmacology},
  year={2006},
  volume={149 6},
  pages={
          687-702
        }
}
BACKGROUND AND PURPOSE Glycogen synthase kinase-3 (GSK-3) is a ubiquitous serine-threonine protein kinase that participates in a multitude of cellular processes and has recently been implicated in the pathophysiology of a number of diseases. The aim of this study was to investigate the effects of GSK-3beta inhibition in a model of acute inflammation. Here, we have investigated the effects of TDZD-8, a potent and selective GSK-3beta inhibitor, in a mouse model of carrageenan-induced pleurisy… 
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22 Citations

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