Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.

@article{King2005InhibitionOG,
  title={Inhibition of glycogen synthase kinase-3 protects cells from intrinsic but not extrinsic oxidative stress.},
  author={Taj D. King and Richard Scott Jope},
  journal={Neuroreport},
  year={2005},
  volume={16 6},
  pages={597-601}
}
Oxidative stress is linked to neuronal dysfunction and death in many diseases. Glycogen synthase kinase-3 often promotes apoptosis, so this investigation tested whether glycogen synthase kinase-3 is linked to oxidative stress-induced apoptosis. Both intrinsic oxidative stress induced by the mitochondrial inhibitor rotenone and extrinsic oxidative stress induced by exogenously added H2O2 activated Bax, caspase-2, and caspase-3 in human neuroblastoma SH-SY5Y cells. Inhibitors of glycogen synthase… CONTINUE READING
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