Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock.

@article{Jellestad2014InhibitionOG,
  title={Inhibition of glycogen synthase kinase (GSK)-3-β improves liver microcirculation and hepatocellular function after hemorrhagic shock.},
  author={Lena Jellestad and Tobias Fink and Sascha Pradarutti and Darius Kubulus and Beate Wolf and I. Bauer and Chris Thiemermann and Hauke Rensing},
  journal={European journal of pharmacology},
  year={2014},
  volume={724},
  pages={175-84}
}
Ischemia and reperfusion may cause liver injury and are characterized by hepatic microperfusion failure and a decreased hepatocellular function. Inhibition of glycogen synthase kinase (GSK)-3β, a serine-threonine kinase that has recently emerged as a key regulator in the modulation of the inflammatory response after stress events, may be protective in conditions like sepsis, inflammation and shock. Therefore, aim of the study was to assess the role of GSK-3β in liver microcirculation and… CONTINUE READING

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