Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

@inproceedings{Yue2016InhibitionOG,
  title={Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity},
  author={Jessica T. Y. Yue and Mona A. Abraham and Paige V. Bauer and Mary P. LaPierre and Peili Wang and Frank A. Duca and Beatrice M. Filippi and Owen Chan and Tony K. T. Lam},
  booktitle={Nature communications},
  year={2016}
}
Impaired glucose homeostasis and energy balance are integral to the pathophysiology of diabetes and obesity. Here we show that administration of a glycine transporter 1 (GlyT1) inhibitor, or molecular GlyT1 knockdown, in the dorsal vagal complex (DVC) suppresses glucose production, increases glucose tolerance and reduces food intake and body weight gain in healthy, obese and diabetic rats. These findings provide proof of concept that GlyT1 inhibition in the brain improves glucose and energy… CONTINUE READING

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