Inhibition of glyceraldehyde 3-phosphate dehydrogenase by plasma and serum ultrafiltrates due in part to a low-molecular-weight, nonpeptide material.

@article{Schwartz1975InhibitionOG,
  title={Inhibition of glyceraldehyde 3-phosphate dehydrogenase by plasma and serum ultrafiltrates due in part to a low-molecular-weight, nonpeptide material.},
  author={Peter L. Schwartz and I M Turfus},
  journal={Metabolism: clinical and experimental},
  year={1975},
  volume={24 5},
  pages={569-72}
}
In an attempt to verify the existence in the blood of a diabetogenic peptide (somantin) derived from growth hormone, ultrafiltrates from plasma and serum from normal and diabetic subjects were prepared. The freeze-dried residues of these ultrafiltrates inhibited glyceraldehyde 3-phosphate dehydrogenase as somantin is claimed to do. However, the behavior of the inhibitory material on gel filtration on Sephadex G-10 indicated a molecular weight well below 700, rather than the considerably larger… CONTINUE READING

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