Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons.

@article{Yamauchi2003InhibitionOG,
  title={Inhibition of glutamate-induced nitric oxide synthase activation by dopamine in cultured rat retinal neurons.},
  author={Tomofusa Yamauchi and Satoshi Kashii and Hiroki Yasuyoshi and Shen Zhang and Y. Hasegawa Honda and Hisamitsu Ujihara and Akinori Akaike},
  journal={Neuroscience letters},
  year={2003},
  volume={347 3},
  pages={155-8}
}
Previously, we showed that dopamine protects cultured retinal neurons from N-methyl-D-aspartate (NMDA) receptor mediated-glutamate excitotoxicity via dopamine D1 receptor. This study has demonstrated for the first time that nitric oxide synthase (NOS) plays a crucial role in dopamine-induced neuroprotection. Our patch clamp study has shown that dopamine does not affect the NMDA-induced whole cell current. Dopamine or SKF38393 (D1 receptor agonist) inhibited ionomycin (calcium ionophore)-induced… CONTINUE READING